Impactful science magnifying glass

Our Study Impact through the Decades impactful science

MACS began 1984 •

WIHS began 1993 •

MWCCS began 2019

1980s

HIV Outcomes • Early HIV Medicine

1990s

Cancer • Early HIV Medicine • HIV Pathogenesis

2000s

Aging and Multimorbidity • Diabetes and Adiposity • Mental Health and Stigma • Cardiovascular • Liver • HIV Outcomes • Social Determinants of Health/Health Disparaties

2010s

Mental Health and Stigma • Aging and Multimorbidity • Cardiovascular • Liver • Sex Hormones and Bone Health

2020s

Aging and Multimorbidity • Sex Hormones and Bone Health • Cancer • Diabetes and Adiposity • Pulmonary

IMPACTFUL SCIENCE - 1980s (105 published papers)

- 1987
- Immune system changes in people with HIV
- 1987
- Low CD4 and high CD8 predict AIDS
- 1987
- Receptive anal sex accounts for nearly all new HIV among men who have sex with men
- 1989
- Low prevalence of neurological problems in otherwise healthy men with HIV

* Affiliated Paper Topic

IMPACTFUL SCIENCE - 1990s (664 published papers)

- 1990
- Pneumocystis pneumonia unlikely if CD4 above 200
- 1996
- CCR5 gene mutation leads to resistance to aquiring HIV
- 1996
- HIV-1 viremia predicts poor outcomes
- 1996
- Kaposi’s Sarcoma Caused by Virus
- 1998
- HIV therapy increases time to AIDS
- 1999
- High rate of Pap smear abnormalities in women with HIV

* Affiliated Paper Topic

IMPACTFUL SCIENCE - 2000s (711 published papers)

- 2000
- Intimate partner violence and childhood sexual abuse very common among WIHS women
- 2002
- HIV increases risk of liver-related death from chronic hepatitis B
- 2002
- Most deaths in women with HIV not related to AIDS
- 2003
- HIV Lowers Good Cholesterol
- 2004
- Untreated depression increases risk of AIDS-related death in women with HIV
- 2005
- Diabetes risk 4 times higher in men with HIV v men without HIV
- 2007
- Frailty more common in men with HIV

* Affiliated Paper Topic

IMPACTFUL SCIENCE - 2010s (1,326 published papers)

- 2013
- Incident hepatitis C in men who have sex with men
- 2014
- High risk coronary artery plaque more common in men with HIV
- 2015
- Aging-related changes in DNA seen earlier in people with HIV
- 2015
- Lung damage in HIV infection increases lung cancer risk
- 2015
- * Middle-aged women with HIV have a higher adjusted fracture rate than women without HIV
- 2016
- Self stigma about HIV reduces adherence to HIV medications
- 2017
- * Earlier risk of fractures in older men with HIV

* Affiliated Paper Topic

IMPACTFUL SCIENCE - 2020s (497 published papers)

- 2020
- * HIV associated with impaired respiratory gas exchange in men
- 2020
- Integrase inhibitors related to weight gain in women with HIV
- 2021
- Cervical cancer screening strategy reduces unnecessary testing in women with HIV
- 2021
- Menopause related to cognition in WIHS women
- 2023
- Aging-related comorbidity burden higher in women than men with HIV
- 2023
- * HIV associated with impaired respiratory gas exchange in women
- 2024
- ART does not fully reverse the accelerated biological aging in HIV
- 2024
- HIV Detected at Low Levels May Lead to Health Problems
- 2025
- HIV Reservoir Linked to Brain Function
- 2025
- HIV-related blood protein signature linked to heart remodeling and heart failure
- 2025
- Weight change after InSTI switch 2-fold higher in women than men

* Affiliated Paper Topic

HIV Outcomes • Early HIV Medicine

Cancer • Early HIV Medicine • HIV Pathogenesis

Aging and Multimorbidity • Diabetes and Adiposity • Mental Health and Stigma • Cardiovascular • Liver • HIV Outcomes • Social Determinants of Health/Health Disparaties

Mental Health and Stigma • Aging and Multimorbidity • Cardiovascular • Liver • Sex Hormones and Bone Health

Aging and Multimorbidity • Sex Hormones and Bone Health • Cancer • Diabetes and Adiposity • Pulmonary

Explore MWCCS Publications >

MWCCS Publications 2019 - 2025

By Year

Cumulative

3,461 Total Publications Since 1984!

# of Publications

Year

3,461 Total Publications Since 1984!

MWCCS 2025 Publications by Topic Area (N=91)

KEY:
CVD: Cardiovascular Disease
HPV: Human Papillomavirus
STI: Sexually Transmitted Infection

*Other topics include:

Sleep: 2, Vision: 1, Renal: 1, STI: 1, Microbiome: 1, Gynecology: 1

NOW AVAILABLE:

Data on Key Intensive Measurements for 1000s of Participants

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MWCCS as a Platform

0K+%

Ancillary Grants Across 17 Topic Areas

0K+%

Clinical Research Sites

0K+%

Participants Enrolled

0K+%

Linked Career Development Awards Funded

0K+%

Ancillary Grants Awarded to External Collaborators

0K+%

Early Stage Investigators Supported Since 2019

ESI Spotlight:

Featured ESI Papers

NIH defines an Early Stage Investigator (ESI) as a Program Director / Principal Investigator (PD/PI) who has completed their terminal research degree or end of post-graduate clinical training, whichever date is later, within the past 10 years and who has not previously competed successfully as PD/PI for a substantial NIH independent research award.

MWCCS Publications 2019 - 2025

MWCCS 2025 Publications by Topic Area (N=91)

NOW AVAILABLE:

MWCCS as a Platform

ESI Spotlight:

Featured ESI Papers

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